On a theory of cell-decision making in multicellular systems

To address the latter, I proposed the Least Environmental Uncertainty Principle (LEUP) as a candidate theory to understand cell decisions. In particular, LEUP uses statistical physics tools that allows for (i) a low-dimensional description of relevant dynamics, and (ii) coupling between single-cell decisions and the corresponding collective behavior at the multicellular level. Finally, I will outline the main mathematical premises of the proposed theory and application to cell decision-making related to collective migration, tissue development and tumor growth. 

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